质子偶联锌反向转运蛋白 SLC30A5 (溶质载体家族30成员5) (锌转运蛋白5) (ZnT-5) (ZnT样转运蛋白1) (hZTL1)
质子偶联锌反向转运蛋白 SLC30A5 (溶质载体家族30成员5) (锌转运蛋白5) (ZnT-5) (ZnT样转运蛋白1) (hZTL1)
Q8TAD4功能描述
与SLC30A6共同形成功能性质子偶联锌离子反向转运蛋白，介导锌沿分泌途径进入细胞器腔 (PubMed:11904301, PubMed:15525635, PubMed:15994300, PubMed:19366695, PubMed:22529353)。通过维持早期分泌途径内的锌离子稳态，调节酶（如碱性磷酸酶和参与磷脂酰肌醇聚糖锚生物合成的酶）的激活与折叠 (PubMed:15525635, PubMed:15994300, PubMed:16636052, PubMed:35525268)。通过将锌转运至胰腺β细胞的分泌颗粒，在胰岛素的储存和分泌中发挥重要作用 (PubMed:11904301)。 {ECO:0000269|PubMed:11904301, ECO:0000269|PubMed:15525635, ECO:0000269|PubMed:15994300, ECO:0000269|PubMed:16636052, ECO:0000269|PubMed:19366695, ECO:0000269|PubMed:22529353, ECO:0000269|PubMed:35525268}.; FUNCTION: [Isoform 2]: 锌离子:质子反向转运蛋白，介导质膜处锌的流入和流出。 {ECO:0000269|PubMed:11937503, ECO:0000269|PubMed:17355957}.
组织特异性
Ubiquitously expressed (PubMed:11904301, PubMed:12095919). Highly expressed in pancreas, liver and kidney (PubMed:11904301). Expressed abundantly in insulin-containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells (at protein level) (PubMed:11904301).
亚细胞定位
Golgi apparatus, Golgi stack membrane
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