SLC28A2 O43868

钠/核苷协同转运蛋白 2 (浓缩型核苷转运蛋白 2) (CNT 2) (hCNT2) (Na(+)/核苷协同转运蛋白 2) (钠偶联核苷转运蛋白 2) (钠/嘌呤核苷协同转运蛋白) (SPNT) (溶质载体家族28成员2)

功能描述

钠依赖性和嘌呤选择性转运蛋白 (PubMed:10087507, PubMed:9435697)。表现出核苷转运系统 cif 或 N1 亚型 (N1/cif) 的转运特征（对嘌呤核苷和尿苷具有选择性）(PubMed:10087507, PubMed:21795683, PubMed:9435697)。在肾脏和其他组织中嘌呤核苷的特异性摄取和补救中起关键作用 (PubMed:9435697)。可能有助于调节睾丸中有机化合物跨越血睾屏障的转运 (Probable)。 {ECO:0000269|PubMed:10087507, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:9435697, ECO:0000305|PubMed:35307651}。

组织特异性

Expressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas, placenta and brain (PubMed:9435697). Weak expression in lung (PubMed:9435697). In testis, primarily localized to the apicolateral membranes of Sertoli cells and vascular endothelial cells, and weakly expressed in Leydig cells, peritubular myoid cells and germ cells (PubMed:35307651).

亚细胞定位

Membrane