睾丸阴离子转运蛋白1 (阴离子交换转运蛋白) (溶质载体家族26成员8)
睾丸阴离子转运蛋白1 (阴离子交换转运蛋白) (溶质载体家族26成员8)
Q96RN1功能描述
介导硫酸盐和草酸盐与氯离子跨膜交换的抗向转运蛋白 (PubMed:11278976, PubMed:11834742)。刺激CFTR的阴离子转运活性 (PubMed:22121115, PubMed:23582645)。可能在精子活力和精子获能期间调节ADCY10/PKA通路激活所需的氯离子和碳酸氢根离子流动方面与CFTR协同作用 (By similarity)。可能在精子尾部分化和运动中发挥作用，从而影响雄性生育力 (By similarity)。 {ECO:0000250|UniProtKB:Q8R0C3, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11834742, ECO:0000269|PubMed:22121115, ECO:0000269|PubMed:23582645}。
组织特异性
Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell (PubMed:11834742). Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids (PubMed:11278976, PubMed:11834742).
亚细胞定位
Membrane
关键词