溶质载体家族22成员16 (肉碱转运蛋白2) (CT2) (果蝇样推定转运蛋白2) (FLIPT2) (Flipt 2) (有机阳离子转运蛋白OKB1) (有机阳离子/肉碱转运蛋白6)
溶质载体家族22成员16 (肉碱转运蛋白2) (CT2) (果蝇样推定转运蛋白2) (FLIPT2) (Flipt 2) (有机阳离子转运蛋白OKB1) (有机阳离子/肉碱转运蛋白6)
Q86VW1功能描述
易化有机阳离子转运蛋白，介导肉碱以及多胺亚精胺的转运 (PubMed:12089149, PubMed:20037140)。介导部分依赖Na(+)的肉碱双向转运 (PubMed:12089149)。可能介导L-肉碱从睾丸附睾上皮分泌至管腔，该过程参与精子的成熟 (PubMed:12089149)。 {ECO:0000269|PubMed:12089149, ECO:0000269|PubMed:20037140}。
组织特异性
Expressed in testis and epididymis (at protein level) (PubMed:12089149, PubMed:12384147, PubMed:15963465). Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase (PubMed:17197897). Expressed at lower levels in adult tissues including bone marrow (at protein level) (PubMed:12372408, PubMed:12384147, PubMed:15963465). Expressed in hematopoietic cells, including CD34(+) leukocytes (PubMed:12384147). Expressed in fetal liver (at protein level), brain, lung, kidney, heart, skeletal muscle, spleen and thymus (PubMed:12372408, PubMed:12384147, PubMed:15963465). Expressed in leukemia cells (PubMed:12384147). Abundantly expressed in ovarian cancer clear-cell adenocarcinoma (PubMed:17581421).
亚细胞定位
Cell membrane
关键词