溶质载体家族12成员4 (电中性钾氯共转运蛋白1) (红细胞K-Cl共转运蛋白1) (hKCC1)
溶质载体家族12成员4 (电中性钾氯共转运蛋白1) (红细胞K-Cl共转运蛋白1) (hKCC1)
Q9UP95功能描述
介导由细胞肿胀激活的电中性钾-氯共转运 (PubMed:35759661)。可能有助于单细胞内的细胞体积稳态 (PubMed:10913127, PubMed:34031912)。可能参与NaCl吸收上皮中基底侧Cl(-)排出的调节 (By similarity)。 {ECO:0000250|UniProtKB:Q9JIS8, ECO:0000269|PubMed:10913127, ECO:0000269|PubMed:34031912, ECO:0000269|PubMed:35759661}.; FUNCTION: [Isoform 4]: 无转运蛋白活性。 {ECO:0000269|PubMed:11551954}.
组织特异性
Ubiquitous (PubMed:8663127, PubMed:9516379). Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes (PubMed:9516379). This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS (PubMed:9516379).
亚细胞定位
Cell membrane
关键词