溶质载体家族12成员3 (Na-Cl共转运蛋白) (NCC) (Na-Cl同向转运蛋白) (噻嗪类敏感性氯化钠共转运蛋白)
溶质载体家族12成员3 (Na-Cl共转运蛋白) (NCC) (Na-Cl同向转运蛋白) (噻嗪类敏感性氯化钠共转运蛋白)
P55017功能描述
电中性的钠离子和氯离子共转运蛋白，作为肾脏远曲小管中钠和氯重吸收的关键介质 (PubMed:18270262, PubMed:21613606, PubMed:22009145, PubMed:36351028, PubMed:36792826)。也作为促炎细胞因子IL18的受体，从而促进IL18诱导的细胞因子产生，包括IFNG、IL6、IL18和CCL2 (By similarity)。可能独立于IL18R1起作用，或与IL18R1形成复合物起作用 (By similarity)。 {ECO:0000250|UniProtKB:P59158, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:22009145, ECO:0000269|PubMed:36351028, ECO:0000269|PubMed:36792826}。
组织特异性
Predominantly expressed in the kidney (at protein level) (PubMed:29993276, PubMed:8812482). Localizes to the distal convoluted tubules (at protein level) (PubMed:29993276). Not detected in normal aorta, but abundantly expressed in fatty streaks and advanced atherosclerotic lesions (at protein level) (PubMed:26099046).
亚细胞定位
Cell membrane
关键词