钠/胆汁酸共转运蛋白7 (Na(+)/胆汁酸共转运蛋白7) (溶质载体家族10成员7)
钠/胆汁酸共转运蛋白7 (Na(+)/胆汁酸共转运蛋白7) (溶质载体家族10成员7)
Q0GE19功能描述
参与牙齿和骨骼发育。在糖胺聚糖和糖蛋白的生物合成与转运中发挥重要作用，以产生功能正常的细胞外基质。细胞外基质矿化所必需 (PubMed:29878199, PubMed:30082715)。也参与细胞钙稳态的调节 (PubMed:30082715, PubMed:31191616)。对胆汁酸或类固醇硫酸盐（包括牛磺胆酸、胆酸、鹅去氧胆酸、雌酮-3-硫酸、脱氢表雄酮硫酸 (DHEAS) 和孕烯醇酮硫酸）不显示转运活性。 {ECO:0000269|PubMed:17628207, ECO:0000269|PubMed:29878199, ECO:0000269|PubMed:30082715, ECO:0000269|PubMed:31191616}。
组织特异性
Widely expressed (PubMed:15932064, PubMed:17628207). Expressed at high levels in liver and at lower levels in prostate, placenta, kidney, heart, lung, thymus and spleen (PubMed:15932064, PubMed:17628207). Strongly expressed in testis and also detected in brain, ovary, colon and small intestine (PubMed:17628207). Weakly expressed in testis and not detected in brain, ovary, colon or small intestine (PubMed:15932064). Isoform 1: Expressed in liver, testis and placenta (PubMed:17628207). Isoform 4: Expressed in liver, testis and placenta (PubMed:17628207).
亚细胞定位
Cell membrane
关键词