SLA2 Q9H6Q3

Src样适配器2 (抗原受体信号传导调节因子) (MARS) (Src样适配蛋白2) (SLAP-2)

功能描述

衔接蛋白，负向调节T细胞受体(TCR)信号传导。抑制T细胞抗原受体诱导的活化T细胞核因子的活化。可能通过连接信号蛋白（如ZAP70）与CBL起作用，导致信号蛋白发生CBL依赖性降解。 {ECO:0000269|PubMed:11696592}。

组织特异性

Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon.

亚细胞定位

Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane. Cytoplasmic vesicle. Note=Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm