SKAP1 Q86WV1

Src激酶相关磷蛋白1 (Src家族相关磷蛋白1) (Src激酶相关55 kDa蛋白) (SKAP-55) (pp55)

蛋白质信息 (UniProt)

Src激酶相关磷蛋白1 (Src家族相关磷蛋白1) (Src激酶相关55 kDa蛋白) (SKAP-55) (pp55)

Q86WV1

功能描述

通过增强MAP激酶途径正向调节T细胞受体信号传导。通过促进T细胞表面整合素ITGAL的聚集，为T细胞与抗原呈递细胞之间的最佳结合所必需。可能参与肥大细胞中高亲和力免疫球蛋白epsilon受体信号传导。 {ECO:0000269|PubMed:10856234, ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:12652296, ECO:0000269|PubMed:15939789, ECO:0000269|PubMed:16980616}.

组织特异性

Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level).

亚细胞定位

Cytoplasm

关键词

3D-structure Adaptive immunity Alternative splicing Cell membrane Cytoplasm Direct protein sequencing Immunity Membrane Nucleus Phosphoprotein

外部链接

UniProt: Q86WV1

NCBI Gene

GeneCards