SIVA1 O15304

凋亡调节蛋白Siva (CD27结合蛋白) (CD27BP)

蛋白质信息 (UniProt)

凋亡调节蛋白Siva (CD27结合蛋白) (CD27BP)

O15304

功能描述

诱导CD27介导的细胞凋亡。抑制BCL2L1同工型Bcl-x(L)的抗凋亡活性。抑制NF-kappa-B的激活并促进T细胞受体介导的细胞凋亡。 {ECO:0000269|PubMed:12011449, ECO:0000269|PubMed:14739602, ECO:0000269|PubMed:15034012, ECO:0000269|PubMed:15958577, ECO:0000269|PubMed:16491128}.

组织特异性

Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon.

亚细胞定位

Cytoplasm

关键词

Alternative splicing Apoptosis Cytoplasm Host-virus interaction Metal-binding Nucleus Pharmaceutical Phosphoprotein Proteomics identification Reference proteome

外部链接

UniProt: O15304

NCBI Gene

GeneCards