SIT1 Q9Y3P8

信号阈值调节跨膜接头蛋白1 (SHP2相互作用跨膜接头蛋白) (抑制诱导跨膜接头蛋白1) (gp30/40)

功能描述

负向调节T细胞中TCR (T-cell antigen receptor)介导的信号传导。参与T细胞的阳性选择。 {ECO:0000269|PubMed:10209036}.

组织特异性

Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level). Expressed in T- and B-cell lymphoma.

亚细胞定位

Cell membrane