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SH3RF2 Q8TEC5

E3泛素蛋白连接酶SH3RF2 (EC 2.3.2.27) (心脏蛋白磷酸酶1结合蛋白) (HEPP1) (POSH消除RING蛋白) (蛋白磷酸酶1调节亚基39) (环指蛋白158) (RING型E3泛素转移酶SH3RF2) (含SH3结构域环指蛋白2)

蛋白质信息 (UniProt)

E3泛素蛋白连接酶SH3RF2 (EC 2.3.2.27) (心脏蛋白磷酸酶1结合蛋白) (HEPP1) (POSH消除RING蛋白) (蛋白磷酸酶1调节亚基39) (环指蛋白158) (RING型E3泛素转移酶SH3RF2) (含SH3结构域环指蛋白2)

Q8TEC5

功能描述

具有E3泛素-蛋白连接酶活性 (PubMed:24130170)。作为JNK通路的抗凋亡调节因子，通过泛素化并促进SH3RF1的降解，SH3RF1是促凋亡JNK激活所需的支架蛋白 (PubMed:22128169)。促进TNF介导的接头蛋白TRADD和RIPK1募集至TNFRSF1A，并通过抑制其泛素介导的蛋白酶体降解来调节PAK4蛋白稳定性 (PubMed:24130170)。抑制PPP1CA磷酸酶活性 (PubMed:19389623, PubMed:19945436)。 {ECO:0000269|PubMed:19389623, ECO:0000269|PubMed:19945436, ECO:0000269|PubMed:22128169, ECO:0000269|PubMed:24130170}。

组织特异性

Heart (at protein level). Up-regulated in colon cancer tissues as compared to normal colon tissues (at protein level). Testis. In the heart, present in the apex, left atrium, right atrium, left ventricle and right ventricle, but not in the aorta.

亚细胞定位

Nucleus

关键词

Alternative splicing Metal-binding Nucleus Phosphoprotein Protein phosphatase inhibitor Proteomics identification Reference proteome Repeat SH3 domain Transferase

外部链接

UniProt: Q8TEC5
NCBI Gene