SH2D2A Q9NP31

含SH2结构域蛋白2A (含SH2结构域接头蛋白) (T细胞特异性接头蛋白) (TSAd) (VEGF受体相关蛋白)

功能描述

可能是一种参与控制T细胞激活的T细胞特异性接头蛋白。可能在CD4-p56-LCK依赖性信号转导通路中发挥作用。也可能在正常和病理性血管生成中发挥重要作用。可能是一种接头蛋白，促进并调节KDR与对内皮细胞存活和增殖重要的效应蛋白之间的相互作用。

组织特异性

Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in unstimulated T-cells, but not expressed in normal resting or activated B-cells. According to PubMed:10692392, expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium and other cell and tissue types, such as heart, lung, and liver.

亚细胞定位

Cytoplasm.