SERPINA3 P01011

α-1-抗糜蛋白酶 (ACT) (细胞生长抑制基因 24/25 蛋白) (Serpin A3) [切割为：缺 His-Pro 的 α-1-抗糜蛋白酶]

蛋白质信息 (UniProt)

α-1-抗糜蛋白酶 (ACT) (细胞生长抑制基因 24/25 蛋白) (Serpin A3) [切割为：缺 His-Pro 的 α-1-抗糜蛋白酶]

P01011

功能描述

尽管其生理功能尚不清楚，但它能抑制中性粒细胞组织蛋白酶G和肥大细胞糜酶，这两种酶均可将血管紧张素-1转化为活性的血管紧张素-2。 {ECO:0000269|PubMed:2404007}。

组织特异性

Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.

亚细胞定位

Secreted.

关键词

3D-structure Acute phase Alternative splicing Direct protein sequencing Glycoprotein Protease inhibitor Proteomics identification Reference proteome Secreted Serine protease inhibitor

外部链接

UniProt: P01011

NCBI Gene

GeneCards