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SEMA6D Q8NFY4

信号素-6D

蛋白质信息 (UniProt)

信号素-6D

Q8NFY4

功能描述

在体外显示对背根神经节(DRG)神经元的生长锥塌陷活性。可能是DRG神经元在其靶区以及其他神经元的停止信号。可能也参与神经连接的维持和重塑。在树突状细胞中作为TREM2的配体,以PLXNA1为共受体,在免疫反应的产生和骨骼稳态中发挥作用(By similarity)。 {ECO:0000250|UniProtKB:Q76KF0}。

亚细胞定位

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm.

关键词

Alternative splicing Cell membrane Cytoplasm Developmental protein Differentiation Disulfide bond Glycoprotein Membrane Neurogenesis Phosphoprotein