SDR16C5 Q8N3Y7

表皮视黄醇脱氢酶2 (EPHD-2) (RDH-E2) (EC 1.1.1.105) (视黄醛短链脱氢酶还原酶2) (retSDR2) (短链脱氢酶/还原酶家族16C成员5)

功能描述

对NAD具有强烈偏好的氧化还原酶 (PubMed:18926804)。在氧化和还原方向均有活性 (PubMed:18926804)。将全反式视黄醇氧化为全反式视黄醛 (PubMed:18926804)。以11-顺式视黄醇或11-顺式视黄醛为底物，无论以NAD(+)/NADH还是NADP(+)/NADPH为辅因子，均未检测到活性 (PubMed:18926804)。 {ECO:0000269|PubMed:18926804}。

组织特异性

Detected in adult lung. Detected at low levels in adult brain, heart, testis, placenta, cervix, pancreas, uterus, stomach, rectum, small intestine, colon, esophagus, thymus, skin, and skin keratinocyte. Expression is higher in psoriasis lesions relative to unaffected skin from psoriasis patients. Detected in fetal kidney, skin and lung.

亚细胞定位

Endoplasmic reticulum membrane