SCTR P47872

分泌素受体 (SCT-R) (SECR)

功能描述

G protein-coupled receptor activated by secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:25332973, PubMed:32811827, PubMed:33008599, PubMed:7612008). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and activates cAMP-dependent pathway (PubMed:32811827, PubMed:33008599). Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:P11384, ECO:0000250|UniProtKB:Q5FWI2, ECO:0000269|PubMed:32811827, ECO:0000269|PubMed:33008599, ECO:0000269|PubMed:7612008, ECO:0000303|PubMed:25332973}. 翻译结果： FUNCTION: 由secretin (SCT)激活的G protein-coupled receptor，参与不同的过程，如调节十二指肠内容物的pH值、食物摄入和水稳态 (PubMed:25332973, PubMed:32811827, PubMed:33008599, PubMed:7612008)。配体结合引起构象变化，通过鸟苷酸结合蛋白 (G proteins) 触发信号传导并激活cAMP依赖性途径 (PubMed:32811827, PubMed:33008599)。与secretin结合后，通过 (1) 抑制胃壁细胞分泌胃酸和 (2) 刺激胰腺导管细胞产生碳酸氢盐 (NaHCO(3)) 来调节十二指肠的pH值 (By similarity)。除了调节十二指肠内容物的pH值外，还在饮食诱导的产热中起核心作用：作为介导餐后产热的非交感神经棕色脂肪 (BAT) 激活剂，从而诱导饱腹感。机制上，餐后肠道释放的secretin与棕色脂肪细胞中的secretin receptor (SCTR) 结合，通过刺激脂解作用激活棕色脂肪产热，这在脑中被感知并促进饱腹感。也能够刺激白色脂肪细胞中的脂解作用。还通过调节肾脏水分重吸收在细胞渗透调节中发挥重要作用。还在中枢神经系统中发挥作用：为突触可塑性所必需 (By similarity)。 {ECO:0000250|UniProtKB:P11384, ECO:0000250|UniProtKB:Q5FWI2, ECO:0000269|PubMed:32811827, ECO:0000269|PubMed:33008599, ECO:0000269|PubMed:7612008, ECO:0000303|PubMed:25332973}。

亚细胞定位

Cell membrane