SCO1 O75880

细胞色素c氧化酶组装因子SCO1

蛋白质信息 (UniProt)

细胞色素c氧化酶组装因子SCO1

O75880

功能描述

铜金属伴侣，对于细胞色素c氧化酶亚基II (MT-CO2/COX2) 的成熟至关重要。与SCO2协同，参与将铜递送至MT-CO2/COX2上的Cu(A)位点 (PubMed:15229189, PubMed:15659396, PubMed:16735468, PubMed:17189203, PubMed:19336478)。通过控制铜转运蛋白CTR1的丰度和细胞膜定位，在铜稳态调节中发挥重要作用 (By similarity)。 {ECO:0000250|UniProtKB:Q5SUC9, ECO:0000269|PubMed:15229189, ECO:0000269|PubMed:15659396, ECO:0000269|PubMed:16735468, ECO:0000269|PubMed:17189203, ECO:0000269|PubMed:19336478}。

组织特异性

Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.

亚细胞定位

Mitochondrion inner membrane

关键词

3D-structure Chaperone Copper Cytochrome c-type biogenesis Disease variant Disulfide bond Membrane Metal-binding Mitochondrion Mitochondrion inner membrane

外部链接

UniProt: O75880

NCBI Gene

GeneCards