SCGB3A2 Q96PL1

分泌球蛋白家族3A成员2 (肺分泌蛋白1) (PnSP-1) (子宫球蛋白相关蛋白1)

功能描述

分泌型细胞因子样蛋白 (PubMed:12847263)。结合清道夫受体MARCO (PubMed:12847263)。也能结合病原体，包括革兰氏阳性菌单核细胞增生李斯特菌、革兰氏阴性菌铜绿假单胞菌和酵母菌 (PubMed:12847263)。强烈抑制磷脂酶A2 (PLA2G1B) 活性 (PubMed:24213919)。似乎在呼吸道上皮中具有抗炎作用 (By similarity)。在肺中亦具有抗纤维化活性 (PubMed:24213919)。可能在胎儿肺部发育和成熟中发挥作用 (PubMed:24213919)。在肺发育早期促进分支形态发生 (PubMed:24213919)。在垂体中，可能抑制卵泡刺激素 (FSH) 和黄体生成素 (LH) 的产生 (By similarity)。 {ECO:0000250|UniProtKB:Q920H1, ECO:0000269|PubMed:12847263, ECO:0000269|PubMed:24213919}.

组织特异性

Highly expressed in lung and trachea (PubMed:12175512, PubMed:12406855, PubMed:12847263). Detected throughout the airway epithelium in lung, with slightly higher expression in large airways (PubMed:12406855). Found in lung submucosal gland acinus where it localizes to serous-like cells (PubMed:12406855). Probably expressed in club cells of the bronchioles (PubMed:12847263). Not detected in other tissues tested (PubMed:12847263).

亚细胞定位

Secreted