硬脂酰-CoA去饱和酶5 (EC 1.14.19.1) (脂酰-CoA-去饱和酶4) (HSCD5) (硬脂酰-CoA 9-去饱和酶) (硬脂酰-CoA去饱和酶2)
硬脂酰-CoA去饱和酶5 (EC 1.14.19.1) (脂酰-CoA-去饱和酶4) (HSCD5) (硬脂酰-CoA 9-去饱和酶) (硬脂酰-CoA去饱和酶2)
Q86SK9功能描述
硬脂酰-CoA去饱和酶，利用O(2)和来自还原型细胞色素b5的电子，在饱和脂酰-CoA底物中引入第一个双键。催化在包括棕榈酰-CoA和硬脂酰-CoA在内的脂酰-CoA底物的delta-9位插入顺式双键 (PubMed:15610069, PubMed:15907797, PubMed:22745828)。生成16:1和18:1不饱和脂肪酸的混合物 (PubMed:15610069, PubMed:15907797)。通过下调EGFR/AKT/MAPK和Wnt信号通路参与神经细胞增殖和分化 (PubMed:22745828)。 {ECO:0000269|PubMed:15610069, ECO:0000269|PubMed:15907797, ECO:0000269|PubMed:22745828}。
组织特异性
Detected in fetal brain, and at lower levels in fetal kidney. Detected in adult brain and pancreas, and at lower levels in kidney and lung. Expressed in spiral ganglion cells and the organ of Corti of fetal cochlea (PubMed:31972369).
亚细胞定位
Endoplasmic reticulum membrane
关键词