核糖体成熟蛋白SBDS (Shwachman-Bodian-Diamond综合征蛋白)
核糖体成熟蛋白SBDS (Shwachman-Bodian-Diamond综合征蛋白)
Q9Y3A5功能描述
成熟核糖体的组装和核糖体生物发生所必需。与EFL1一起，触发GTP依赖性的EIF6从细胞质中60S前核糖体上的释放，从而通过允许80S核糖体组装并促进EIF6回收至细胞核，激活核糖体的翻译能力，而在细胞核中，EIF6是60S rRNA加工和核输出所必需的。正常的蛋白质合成水平所必需。可能在细胞应激抵抗中发挥作用。可能在细胞对DNA损伤的反应中发挥作用。可能在细胞增殖中发挥作用。 {ECO:0000269|PubMed:17643419, ECO:0000269|PubMed:19602484, ECO:0000269|PubMed:19759903, ECO:0000269|PubMed:21536732}。
组织特异性
Widely expressed.
亚细胞定位
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:17475909, PubMed:19602484). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (PubMed:19759903).
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