SAPCD2 Q86UD0

含APC抑制因子结构域蛋白2 (肿瘤特异性及有丝分裂期依赖性表达蛋白) (TS/MDEP) (p42.3)

功能描述

在视网膜祖细胞(RPCs)中参与平面有丝分裂纺锤体定向，并促进对称终末分裂的产生 (By similarity)。负向调控GPSM2在有丝分裂顶端皮层的定位 (PubMed:26766442)。还参与细胞增殖和肿瘤细胞生长的正向调控 (PubMed:23576022, PubMed:23704824)。 {ECO:0000250|UniProtKB:Q9D818, ECO:0000269|PubMed:23576022, ECO:0000269|PubMed:23704824, ECO:0000269|PubMed:26766442}。

组织特异性

Expressed in 5-month-old fetal tissues, including stomach, intestine, colon, liver, brain, lung, heart, spleen and kidney (PubMed:17525738). Undetectable in non-cancerous adult tissues (PubMed:17525738). Expressed in many primary gastric carcinoma, but almost not in adjacent normal mucosa (PubMed:17525738). Expressed preferentially in M and G1 phases, compared to S and G2 phases (PubMed:17525738). Expression is up-regulated in hepatocellular carcinoma (HCC) and colorectal cancer (CRC) tissues (at protein level) (PubMed:23704824).

亚细胞定位

Cytoplasm