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SAP30 O75446

组蛋白去乙酰化酶复合体亚基SAP30 (30 kDa Sin3相关多肽) (Sin3辅阻遏复合体亚基SAP30) (Sin3相关多肽p30)

蛋白质信息 (UniProt)

组蛋白去乙酰化酶复合体亚基SAP30 (30 kDa Sin3相关多肽) (Sin3辅阻遏复合体亚基SAP30) (Sin3相关多肽p30)

O75446

功能描述

参与Sin3-组蛋白去乙酰化酶复合物(HDAC)功能性地招募至特定亚群的N-CoR共抑制复合物。能够通过N-CoR进行转录抑制。具有去乙酰化核心组蛋白八聚体的活性(当处于复合物中时),但对核小体组蛋白无去乙酰化活性。 {ECO:0000250|UniProtKB:O88574, ECO:0000269|PubMed:9651585}.; FUNCTION: (微生物感染) 参与HHV-1基因TK和gC的转录抑制。 {ECO:0000269|PubMed:21221920}.

组织特异性

Expressed in all tissues tested with highest levels in pancreas, ovary, PBL, spleen and thymus; lowest levels in brain, placenta, lung and kidney.

亚细胞定位

Nucleus.

关键词

3D-structure DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription