返回首页

SAG P10523

S-抑制蛋白 (48 kDa蛋白) (视网膜S-抗原) (S-AG) (视杆光感受器抑制蛋白)

蛋白质信息 (UniProt)

S-抑制蛋白 (48 kDa蛋白) (视网膜S-抗原) (S-AG) (视杆光感受器抑制蛋白)

P10523

功能描述

结合光活化、磷酸化的RHO,并通过与G-proteins竞争RHO上的同一结合位点来终止经由G-proteins的RHO信号传导 (By similarity)。可能在防止视网膜感光细胞的光依赖性变性中发挥作用 (PubMed:9565049)。 {ECO:0000250|UniProtKB:P08168, ECO:0000305|PubMed:9565049}。

组织特异性

Detected in retina, in the proximal portion of the outer segment of rod photoreceptor cells (at protein level).

亚细胞定位

Cell projection, cilium, photoreceptor outer segment

关键词

Cell projection Congenital stationary night blindness Disease variant Membrane Phosphoprotein Proteomics identification Reference proteome Retinitis pigmentosa