1-磷酸鞘氨醇受体5 (S1P受体5) (S1P5) (内皮分化G蛋白偶联受体8) (1-磷酸鞘氨醇受体Edg-8) (S1P受体Edg-8)
1-磷酸鞘氨醇受体5 (S1P受体5) (S1P5) (内皮分化G蛋白偶联受体8) (1-磷酸鞘氨醇受体Edg-8) (S1P受体Edg-8)
Q9H228功能描述
溶鞘脂鞘氨醇1-磷酸（S1P）的受体。S1P是一种生物活性溶血磷脂，对大多数类型的细胞和组织引起多种生理效应。与异三聚体G蛋白的G(i/0)alpha和G(12)亚类偶联（通过相似性）。可能在放射状胶质细胞转化为星形胶质细胞的过程中起调节作用，并可能影响这些细胞的增殖活性。{ECO:0000250}。
组织特异性
Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes.
亚细胞定位
Cell membrane; Multi-pass membrane protein.
关键词