S100-P蛋白 (迁移诱导基因9蛋白) (MIG9) (S100-E蛋白) (S100钙结合蛋白P)
S100-P蛋白 (迁移诱导基因9蛋白) (MIG9) (S100-E蛋白) (S100钙结合蛋白P)
P25815功能描述
可能作为钙传感器发挥作用，并参与细胞钙信号传导。以钙依赖的方式，通过与EZR和PPP5C等其他蛋白相互作用发挥功能，并间接参与上皮细胞微绒毛形成等生理过程。可能通过激活晚期糖基化终产物受体(RAGE)以自分泌方式刺激细胞增殖。 {ECO:0000269|PubMed:14617629, ECO:0000269|PubMed:19111582, ECO:0000269|PubMed:22399290}。
组织特异性
Detected in all of the tissues except brain, testis and small intestine, expression level is higher in placenta, heart, lung, skeletal muscle, spleen and leukocyte. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias.
亚细胞定位
Nucleus. Cytoplasm. Cell projection, microvillus membrane. Note=Colocalizes with S100PBP in the nucleus. Colocalizes with EZR in the microvilli in a calcium-dependent manner.
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