RYR3 Q15413

兰尼碱受体3 (RYR-3) (RyR3) (脑兰尼碱受体-钙释放通道) (脑型兰尼碱受体) (3型兰尼碱受体)

功能描述

胞质钙激活钙通道，介导肌肉中肌浆网的Ca(2+)释放到细胞质中，从而在触发肌肉收缩中起作用 (PubMed:12354756, PubMed:9395096)。可能通过其他钙通道调节Ca(2+)释放。在非肌肉细胞中介导内质网Ca(2+)诱导的Ca(2+)释放的钙通道。有助于维持细胞钙离子稳态 (By similarity)。在细胞钙信号传导中起作用。 {ECO:0000250|UniProtKB:Q92736, ECO:0000269|PubMed:12354756, ECO:0000269|PubMed:9395096}。

组织特异性

Brain, skeletal muscle, placenta and possibly liver and kidney. In brain, highest levels are found in the cerebellum, hippocampus, caudate nucleus and amygdala, with lower levels in the corpus callosum, substantia nigra and thalamus.

亚细胞定位

Sarcoplasmic reticulum membrane