GTP结合蛋白RAD (RAD1) (Ras associated with diabetes)
GTP结合蛋白RAD (RAD1) (Ras associated with diabetes)
P55042功能描述
可能调节心肌细胞中基础电压依赖性L型Ca(2+)电流，并为β-肾上腺素能增强Ca(2+)内流所必需，从而调节心率和收缩力的增加 (By similarity)。可能通过强烈抑制电压门控L型Ca(2+)电流在心脏抗心律失常中发挥重要作用 (By similarity)。调节电压依赖性L型钙通道亚基alpha-1C向细胞膜的转运 (By similarity)。通过钙调蛋白依赖性激酶II (CaMKII) 途径抑制心脏肥大 (PubMed:18056528)。抑制CAMK2D的磷酸化和激活 (PubMed:18056528)。 {ECO:0000250|UniProtKB:O88667, ECO:0000269|PubMed:18056528}。
组织特异性
Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.
亚细胞定位
Cell membrane
关键词