RNMT O43148

mRNA帽鸟嘌呤-N(7)甲基转移酶 (EC 2.1.1.56) (RG7MT1) (mRNA (鸟嘌呤-N(7))-甲基转移酶) (mRNA帽甲基转移酶) (hCMT1) (hMet) (hcm1p)

蛋白质信息 (UniProt)

mRNA帽鸟嘌呤-N(7)甲基转移酶 (EC 2.1.1.56) (RG7MT1) (mRNA (鸟嘌呤-N(7))-甲基转移酶) (mRNA帽甲基转移酶) (hCMT1) (hMet) (hcm1p)

O43148

功能描述

mRNA加帽甲基转移酶RNMT:RAMAC复合物的催化亚基，该复合物将添加到mRNA 5'-帽结构的鸟苷N7位甲基化 (PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871, PubMed:9705270, PubMed:9790902)。结合含有5'-末端GpppC的RNA (PubMed:11114884)。 {ECO:0000269|PubMed:10347220, ECO:0000269|PubMed:11114884, ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871, ECO:0000269|PubMed:9705270, ECO:0000269|PubMed:9790902}。

组织特异性

Widely expressed.

亚细胞定位

Nucleus

关键词

3D-structure Alternative splicing Methyltransferase mRNA capping mRNA processing Nucleus Phosphoprotein Proteomics identification Reference proteome RNA-binding

外部链接

UniProt: O43148

NCBI Gene

GeneCards