E3泛素蛋白连接酶RNF135 (EC 2.3.2.27) (RIG-I E3泛素连接酶) (REUL) (环指蛋白135) (导致RIG-I激活的环指蛋白) (Riplet) (RING型E3泛素转移酶RNF135)
E3泛素蛋白连接酶RNF135 (EC 2.3.2.27) (RIG-I E3泛素连接酶) (REUL) (环指蛋白135) (导致RIG-I激活的环指蛋白) (Riplet) (RING型E3泛素转移酶RNF135)
Q8IUD6功能描述
E2依赖性E3泛素-蛋白连接酶，作为RIGI共受体参与细胞质中病毒RNA的感应和抗病毒先天免疫反应的激活 (PubMed:19017631, PubMed:19484123, PubMed:21147464, PubMed:23950712, PubMed:28469175, PubMed:31006531)。与UBE2D3、UBE2N和UB2V1 E2连接酶协同，催化在病毒RNA上寡聚化的RIGI的‘Lys-63’连接的多泛素化，这是激活RIG-I信号通路的关键步骤 (PubMed:19017631, PubMed:21147464, PubMed:28469175, PubMed:31006531)。通过一种不依赖泛素的平行机制，即桥接在较长病毒RNA上形成的RIGI丝状体，进一步激活RIG-I信号通路 (PubMed:31006531)。这种与泛素依赖机制协同作用的第二种机制，从而允许对RIG-I信号通路进行RNA长度依赖性的调节 (Probable)。与E2连接酶UBE2N结合，还组成型合成非锚定的‘Lys-63’连接的多泛素链，这也可能激活RIG-I信号通路 (PubMed:28469175, PubMed:31006531)。 {ECO:0000269|PubMed:19017631, ECO:0000269|PubMed:19484123, ECO:0000269|PubMed:21147464, ECO:0000269|PubMed:23950712, ECO:0000269|PubMed:28469175, ECO:0000269|PubMed:31006531, ECO:0000305|PubMed:31006531}。
组织特异性
Expressed in skeletal muscle, spleen, kidney, placenta, prostate, stomach, thyroid and tongue. Also weakly expressed in heart, thymus, liver and lung.
亚细胞定位
Cytoplasm
关键词