RNF13 O43567

E3泛素蛋白连接酶RNF13 (EC 2.3.2.27) (环指蛋白13)

蛋白质信息 (UniProt)

E3泛素蛋白连接酶RNF13 (EC 2.3.2.27) (环指蛋白13)

O43567

功能描述

E3 ubiquitin-protein ligase，调节细胞增殖 (PubMed:18794910, PubMed:23378536, PubMed:30595371)。参与细胞凋亡调节 (PubMed:23378536, PubMed:30595371)。通过促进ERN1激活和XBP1 mRNA剪接，介导内质网应激诱导的JNK信号通路激活和细胞凋亡 (PubMed:23378536, PubMed:30595371)。也参与蛋白质运输和定位 (PubMed:24387786)。 {ECO:0000269|PubMed:18794910, ECO:0000269|PubMed:23378536, ECO:0000269|PubMed:24387786, ECO:0000269|PubMed:30595371}。

组织特异性

Widely expressed (at protein level). In normal pancreas, expressed in islets, but not in ducts, nor in acini (at protein level).

亚细胞定位

Endoplasmic reticulum membrane

关键词

3D-structure Alternative splicing Disease variant Endoplasmic reticulum Endosome Epilepsy Glycoprotein Lysosome Membrane Metal-binding

外部链接

UniProt: O43567

NCBI Gene

GeneCards