E3泛素蛋白连接酶RNF125 (EC 2.3.2.27) (RING指蛋白125) (T细胞RING激活蛋白1) (TRAC-1)
E3泛素蛋白连接酶RNF125 (EC 2.3.2.27) (RING指蛋白125) (T细胞RING激活蛋白1) (TRAC-1)
Q96EQ8功能描述
E3泛素-蛋白连接酶，介导靶蛋白（如RIGI、MAVS/IPS1、IFIH1/MDA5、JAK1和p53/TP53）的泛素化及随后的蛋白酶体降解 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:25591766, PubMed:26027934, PubMed:26471729, PubMed:27411375)。作为I型干扰素产生的负调节因子，通过介导RIGI在'Lys-181'处的泛素化，导致RIGI降解 (PubMed:17460044, PubMed:26471729)。介导p53/TP53的泛素化及随后的降解 (PubMed:25591766)。介导JAK1的泛素化及随后的降解 (PubMed:26027934)。作为T细胞激活的正调节因子 (PubMed:15843525)。 {ECO:0000269|PubMed:15843525, ECO:0000269|PubMed:17460044, ECO:0000269|PubMed:17643463, ECO:0000269|PubMed:25591766, ECO:0000269|PubMed:26027934, ECO:0000269|PubMed:26471729, ECO:0000269|PubMed:27411375}。
组织特异性
Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4(+) and CD8(+) T-cells, suggesting that it is preferentially confined to T-cells.
亚细胞定位
Golgi apparatus membrane
关键词