核糖核酸酶7 (RNase 7) (EC 3.1.27.-) (皮肤源性抗菌蛋白2) (SAP-2)
核糖核酸酶7 (RNase 7) (EC 3.1.27.-) (皮肤源性抗菌蛋白2) (SAP-2)
Q9H1E1功能描述
表现出强效的RNase活性 (PubMed:12244054, PubMed:12527768, PubMed:17150966)。具有广谱抗菌活性，针对包括尿致病性大肠杆菌(UPEC)在内的多种病原微生物，并且对耐万古霉素的屎肠球菌表现出显著强效的活性（90%致死剂量 < 30 nM）(PubMed:12244054, PubMed:12527768, PubMed:17150966, PubMed:25075772, PubMed:33818125)。导致细菌膜完整性丧失 (PubMed:17150966)。可能有助于尿路无菌 (PubMed:25075772)。杀菌活性不依赖于RNase活性 (PubMed:17150966)。 {ECO:0000269|PubMed:12244054, ECO:0000269|PubMed:12527768, ECO:0000269|PubMed:17150966, ECO:0000269|PubMed:25075772, ECO:0000269|PubMed:33818125}。
组织特异性
Expressed in collecting ducts in kidney, and in apical uroepithelium in bladder (at protein level) (PubMed:25075772). Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut (PubMed:12244054). Expressed in liver, kidney, skeletal muscle and heart (PubMed:12527768).
亚细胞定位
Secreted
关键词