RNASE6 Q93091

核糖核酸酶K6 (RNase K6) (EC 3.1.27.-)

功能描述

核糖核酸酶，对嘧啶尿嘧啶和胞嘧啶显示出偏好性 (PubMed:27013146, PubMed:8836175)。对一系列革兰氏阳性和革兰氏阴性细菌具有强效的抗菌活性，包括铜绿假单胞菌 (P.aeruginosa)、鲍曼不动杆菌 (A.baumanii)、藤黄微球菌 (M.luteus)、金黄色葡萄球菌 (S.aureus)、粪肠球菌 (E.faecalis)、屎肠球菌 (E.faecium)、腐生葡萄球菌 (S.saprophyticus) 和大肠杆菌 (E.coli) (PubMed:25075772, PubMed:27089320)。导致细菌膜完整性丧失，并促进革兰氏阴性细菌的凝集 (PubMed:27089320)。可能有助于泌尿道的无菌状态 (PubMed:25075772)。杀菌活性不依赖于RNase活性 (PubMed:27089320)。 {ECO:0000269|PubMed:25075772, ECO:0000269|PubMed:27013146, ECO:0000269|PubMed:27089320, ECO:0000269|PubMed:8836175}。

组织特异性

Highly expressed in spleen (at protein level) (PubMed:25075772, PubMed:8836175). Has little or no expression in healthy kidneys (at protein level) (PubMed:25075772). Detected in interstitial leukocytes in infected kidneys (at protein level) (PubMed:25075772). Expressed in ureter where it localizes to urothelial and submucosal leukocytes (at protein level) (PubMed:25075772). Strong expression in lung and thymus, and lower expression in heart, placenta, pancreas, liver, brain and skeletal muscle (PubMed:25075772, PubMed:8836175). Also expressed in monocytes and neutrophils (PubMed:8836175).

亚细胞定位

Secreted