核糖体加氧酶2 (60S核糖体蛋白L27a组氨酸羟化酶) (双功能赖氨酸特异性去甲基化酶和组氨酰-羟化酶MINA) (EC 1.14.11.79) (组蛋白赖氨酸去甲基化酶MINA) (MYC诱导核抗原) (矿物粉尘诱导基因蛋白) (核仁蛋白52) (核糖体加氧酶MINA) (ROX)
核糖体加氧酶2 (60S核糖体蛋白L27a组氨酸羟化酶) (双功能赖氨酸特异性去甲基化酶和组氨酰-羟化酶MINA) (EC 1.14.11.79) (组蛋白赖氨酸去甲基化酶MINA) (MYC诱导核抗原) (矿物粉尘诱导基因蛋白) (核仁蛋白52) (核糖体加氧酶MINA) (ROX)
Q8IUF8功能描述
一种加氧酶，既可作为组蛋白赖氨酸去甲基化酶，也可作为核糖体组氨酸羟化酶。参与组蛋白H3上三甲基化'Lys-9' (H3K9me3)的去甲基化，导致核糖体RNA表达增加。还催化60S核糖体蛋白L27a上'His-39'的羟基化。可能在细胞生长和存活中发挥重要作用。可能参与核糖体生物合成，最可能是在前核糖体颗粒的组装过程中。 {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:14695334, ECO:0000269|PubMed:15534111, ECO:0000269|PubMed:15819408, ECO:0000269|PubMed:15897898, ECO:0000269|PubMed:17317935, ECO:0000269|PubMed:19502796, ECO:0000269|PubMed:23103944}。
组织特异性
Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines.
亚细胞定位
Nucleus
关键词