Rho相关GTP结合蛋白RhoU (CDC42样GTP酶1) (GTP结合蛋白样1) (Rho GTP酶样蛋白ARHU) (Ryu GTP酶) (Wnt-1响应Cdc42同源蛋白1) (WRCH-1)
Rho相关GTP结合蛋白RhoU (CDC42样GTP酶1) (GTP结合蛋白样1) (Rho GTP酶样蛋白ARHU) (Ryu GTP酶) (Wnt-1响应Cdc42同源蛋白1) (WRCH-1)
Q7L0Q8功能描述
结合并激活蛋白激酶PAK1 (PubMed:11459829)。在细胞迁移过程中参与调节细胞形态、细胞骨架组织和粘着斑组装 (PubMed:11459829, PubMed:17620058, PubMed:18086875, PubMed:21834987)。亦可刺激静止细胞重新进入细胞周期 (PubMed:11459829)。未检测到GTP酶活性，但其高内在鸟苷酸交换活性表明其呈组成型GTP结合状态 (PubMed:16472646)。 {ECO:0000269|PubMed:11459829, ECO:0000269|PubMed:16472646, ECO:0000269|PubMed:17620058, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:21834987}。
组织特异性
Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta.
亚细胞定位
Cell membrane
关键词