RHOBTB2 Q9BYZ6

含BTB结构域的Rho相关蛋白2 (乳腺癌缺失基因2蛋白) (p83)

蛋白质信息 (UniProt)

含BTB结构域的Rho相关蛋白2 (乳腺癌缺失基因2蛋白) (p83)

Q9BYZ6

功能描述

细胞增殖和凋亡的调节因子 (PubMed:21801820)。它可能作为底物适配器发挥作用，将关键底物（例如 MSI2）募集到基于 CUL3 的泛素连接酶复合物中进行降解 (PubMed:15107402, PubMed:27941885)。MSI2 泛素化和降解所必需 (PubMed:27941885)。 {ECO:0000269|PubMed:15107402, ECO:0000269|PubMed:21801820, ECO:0000269|PubMed:27941885}。

组织特异性

Ubiquitous, with highest levels in neural tissues. Expression is also detected in fetal lung, heart, and brain.

关键词

Alternative splicing Disease variant Epilepsy GTP-binding Nucleotide-binding Proteomics identification Reference proteome Repeat Ubl conjugation Ubl conjugation pathway

外部链接

UniProt: Q9BYZ6

NCBI Gene

GeneCards