RGS1 Q08116

G蛋白信号调节因子1 (RGS1) (B细胞激活蛋白BL34) (早期反应蛋白1R20)

功能描述

调节G蛋白偶联受体信号级联反应，包括N-甲酰肽趋化因子受体和白三烯受体下游的信号传导 (PubMed:10480894)。抑制B细胞向CXCL12的趋化运动 (By similarity)。通过增加G蛋白α亚基的GTP酶活性从而驱动其进入非活性的GDP结合形式来抑制信号转导 (PubMed:10480894, PubMed:18434541)。 {ECO:0000250|UniProtKB:Q9JL25, ECO:0000269|PubMed:10480894, ECO:0000269|PubMed:18434541}。

组织特异性

Detected in peripheral blood monocytes (PubMed:10480894). Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high (PubMed:8473738).

亚细胞定位

Cell membrane