细胞周期调节因子RGCC (补体32反应蛋白) (RGC-32)
细胞周期调节因子RGCC (补体32反应蛋白) (RGC-32)
Q9H4X1功能描述
调节细胞周期特异性激酶的活性。增强CDK1活性。可能参与细胞周期的调节。可能通过促进有丝分裂进程在G2/M期转换时停滞，抑制胶质瘤细胞的生长。通过成纤维细胞活化参与肾纤维化发病机制的致纤维化因子。 {ECO:0000269|PubMed:11687586, ECO:0000269|PubMed:17146433, ECO:0000269|PubMed:19158077, ECO:0000269|PubMed:22163048}.
组织特异性
Detected in brain, heart and liver (at protein level). Highly expressed in liver, skeletal muscle, kidney and pancreas. Detected at lower levels in heart, brain and placenta. Detected in aorta endothelial cells. Overexpressed in colon, breast, prostate, bladder, lung, and ovarian cancer tissues.
亚细胞定位
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase.
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