RETN Q9HD89

抵抗素 (脂肪组织特异性分泌因子) (ADSF) (C/EBP-epsilon调节的髓系特异性分泌富含半胱氨酸蛋白) (富含半胱氨酸分泌蛋白A12-alpha样2) (富含半胱氨酸分泌蛋白FIZZ3)

功能描述

该激素似乎抑制胰岛素刺激脂肪细胞摄取葡萄糖的能力 (By similarity)。可能将肥胖与糖尿病联系起来 (By similarity)。促进髓系细胞的趋化性 (PubMed:15064728)。 {ECO:0000250|UniProtKB:Q99P87, ECO:0000269|PubMed:15064728}。

组织特异性

Expressed in white adipose tissue (at protein level) (PubMed:11201732). Widely expressed, with particularly strong expression in lung, bone marrow, breast and peripheral blood (PubMed:15248836). Expressed strongly in bone marrow and at lower levels in lung, but not detected in other tissues (PubMed:15064728). Isoform 2 is detected in adipose tissue, bone marrow, brain, lung, peripheral blood, placenta and thymus (PubMed:15248836).

亚细胞定位

Secreted