Ras相关雌激素调节生长抑制因子 (EC 3.6.5.2)
Ras相关雌激素调节生长抑制因子 (EC 3.6.5.2)
Q96A58功能描述
结合GDP/GTP并具有内在GTPase活性。对GDP的亲和力高于GTP。在细胞系中，过表达导致增殖速率、集落形成和致瘤潜能降低。 {ECO:0000269|PubMed:11533059}。
组织特异性
Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor-positive breast-derived cell lines, but not in estrogen receptor-negative cell lines. Expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis.
亚细胞定位
Cytoplasm
关键词