REPS2 Q8NFH8

RalBP1相关含Eps结构域蛋白2 (RalBP1伴侣) (RalBP1相互作用蛋白2)

蛋白质信息 (UniProt)

RalBP1相关含Eps结构域蛋白2 (RalBP1伴侣) (RalBP1相互作用蛋白2)

Q8NFH8

功能描述

作为Ral信号通路的一部分，参与EGF和胰岛素受体的配体依赖性受体介导内吞 (PubMed:10393179, PubMed:12771942, PubMed:9422736)。通过控制生长因子受体内吞，可能调节细胞存活 (PubMed:12771942)。通过ASAP1可能调节细胞粘附和迁移 (PubMed:12149250)。 {ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:12149250, ECO:0000269|PubMed:12771942, ECO:0000269|PubMed:9422736}。

组织特异性

Expressed at high levels in the cerebrum, cerebellum, lung, kidney, and testis. Weakly expressed in the kidney. Isoform 2 is down-regulated during progression of prostate cancer.

亚细胞定位

Cytoplasm

关键词

3D-structure Alternative splicing Calcium Coiled coil Cytoplasm Metal-binding Phosphoprotein Proteomics identification Reference proteome Repeat

外部链接

UniProt: Q8NFH8

NCBI Gene

GeneCards