RELN P78509

Reelin (EC 3.4.21.-)

功能描述

由先锋神经元分泌的细胞外基质丝氨酸蛋白酶，通过在神经发育过程中协调细胞定位，在大脑皮层和小脑神经元分层中发挥作用。调节神经元中的微管功能和神经元迁移。与脂蛋白受体VLDLR和LRP8/APOER2的胞外结构域结合，诱导DAB1的酪氨酸磷酸化并调节TAU磷酸化。影响脊髓中交感节前神经元的迁移，在脊髓中似乎充当神经元迁移的屏障。酶活性对于细胞粘附的调节很重要。 {ECO:0000250|UniProtKB:Q60841}。

组织特异性

Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. In adult brain, preferentially expressed in GABAergic interneurons of prefrontal cortices, temporal cortex, hippocampus and glutamatergic granule cells of cerebellum. Expression is reduced to about 50% in patients with schizophrenia. Also expressed in fetal and adult liver.

亚细胞定位

Secreted, extracellular space, extracellular matrix