视黄醇脱氢酶16 (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.315) (EC 1.1.1.53) (人表皮视黄醇脱氢酶) (hRDH-E) (微粒体NAD(+)-依赖性视黄醇脱氢酶4) (RoDH-4) (短链脱氢酶/还原酶家族9C成员8) (固醇/视黄醇脱氢酶)
视黄醇脱氢酶16 (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.315) (EC 1.1.1.53) (人表皮视黄醇脱氢酶) (hRDH-E) (微粒体NAD(+)-依赖性视黄醇脱氢酶4) (RoDH-4) (短链脱氢酶/还原酶家族9C成员8) (固醇/视黄醇脱氢酶)
O75452功能描述
优先利用NAD的氧化还原酶。将全反式视黄醇、9-顺式视黄醇、11-顺式视黄醇和13-顺式视黄醇氧化为相应的醛 (PubMed:10329026, PubMed:12534290, PubMed:9677409)。对CRBP结合型视黄醇的活性高于游离视黄醇 (PubMed:12534290)。也氧化3-α-羟基类固醇。将雄烷二醇和雄酮氧化为双氢睾酮和雄烷二酮。也能催化逆反应 (PubMed:10329026, PubMed:29541409, PubMed:9677409)。 {ECO:0000269|PubMed:10329026, ECO:0000269|PubMed:12534290, ECO:0000269|PubMed:29541409, ECO:0000269|PubMed:9677409}。
组织特异性
Highly expressed in adult liver (at protein level) (PubMed:9677409). Detected in endometrium, liver and foreskin (PubMed:10329026, PubMed:11967490). Detected in the spineous layers of adult skin, and at lower levels in basal and granular skin layers (PubMed:10329026). Detected in fetal liver and lung.
亚细胞定位
Microsome membrane
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