视黄醇脱氢酶11 (EC 1.1.1.300) (雄激素调节短链脱氢酶/还原酶1) (HCV核心蛋白结合蛋白HCBP12) (前列腺短链脱氢酶/还原酶1) (视黄醛还原酶1) (RalR1) (短链脱氢酶/还原酶家族7C成员1)
视黄醇脱氢酶11 (EC 1.1.1.300) (雄激素调节短链脱氢酶/还原酶1) (HCV核心蛋白结合蛋白HCBP12) (前列腺短链脱氢酶/还原酶1) (视黄醛还原酶1) (RalR1) (短链脱氢酶/还原酶家族7C成员1)
Q8TC12功能描述
视黄醇脱氢酶，对NADP有明显的偏好。对9-顺式、11-顺式和全反式视黄醇显示出高活性，对13-顺式视黄醇活性较低 (PubMed:12036956, PubMed:12226107, PubMed:29410696)。对不饱和中链醛（如顺式-6-壬烯醛）表现出较低的还原活性，对壬醛或4-羟基壬烯醛无活性 (PubMed:15865448)。对类固醇无脱氢酶活性 (PubMed:12036956, PubMed:12226107)。 {ECO:0000269|PubMed:12036956, ECO:0000269|PubMed:12226107, ECO:0000269|PubMed:15865448, ECO:0000269|PubMed:29410696}。
组织特异性
Predominantly expressed in the epithelial cells of prostate, in both basal and luminal secretory cell populations. Expressed at low levels in spleen, thymus, testis, ovary, small intestine, colon, peripherical blood leukocytes, kidney, adrenal gland and fetal liver. Not detected in prostatic fibromuscular stromal cells, endothelial cells, or infiltrating lymphocytes.
亚细胞定位
Endoplasmic reticulum membrane
关键词