RD3 Q7Z3Z2

RD3蛋白 (视网膜变性蛋白3)

功能描述

在光感受器核苷酸循环中酶的调节方面发挥关键作用 (PubMed:21078983, PubMed:21928830, PubMed:27471269, PubMed:29515371, PubMed:30559291)。抑制GUCY2D和GUCY2F的基础催化活性和GCAP刺激的活性，这两种视网膜鸟苷酸环化酶参与光感受器中cGMP的产生 (PubMed:21928830, PubMed:27471269, PubMed:29515371, PubMed:30559291)。参与GUCY2D和GUCY2F向其在光感受器外节靶位点的转运 (PubMed:21078983)。上调GUK1的活性，该激酶在回收GMP及间接回收cGMP方面也发挥重要作用 (PubMed:29515371)。对视网膜中视杆细胞和视锥细胞的存活起重要作用 (By similarity)。 {ECO:0000250|UniProtKB:Q8BRE0, ECO:0000269|PubMed:21078983, ECO:0000269|PubMed:21928830, ECO:0000269|PubMed:27471269, ECO:0000269|PubMed:29515371, ECO:0000269|PubMed:30559291}。

组织特异性

Expressed in retina (PubMed:12914764). Widely expressed (at protein level) (PubMed:29030614). In the retina the strongest immunoreactivity is detected in the inner half of the cytoplasmic portion of the photoreceptor layer, where rods and cones are found, and the external half of the outer plexiform layer (at protein level) (PubMed:29030614).

亚细胞定位

Cell projection, cilium, photoreceptor outer segment