RBM39 Q14498

RNA结合蛋白39 (CAPER alpha) (CAPERalpha) (肝细胞癌蛋白1) (RNA结合基序蛋白39) (含RNA结合区蛋白2) (剪接因子HCC1)

蛋白质信息 (UniProt)

RNA结合蛋白39 (CAPER alpha) (CAPERalpha) (肝细胞癌蛋白1) (RNA结合基序蛋白39) (含RNA结合区蛋白2) (剪接因子HCC1)

Q14498

功能描述

RNA结合蛋白，作为pre-mRNA剪接因子发挥作用 (PubMed:15694343, PubMed:24795046, PubMed:28302793, PubMed:28437394, PubMed:31271494)。通过调节外显子盒式剪接促进外显子包含而发挥作用 (PubMed:31271494)。亦作为类固醇核受体ESR1/ER-alpha和ESR2/ER-beta，以及JUN/AP-1的转录共激活因子，且不依赖于pre-mRNA剪接因子活性 (By similarity)。 {ECO:0000250|UniProtKB:Q8VH51, ECO:0000269|PubMed:15694343, ECO:0000269|PubMed:24795046, ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31271494}。

组织特异性

Widely expressed. Highly expressed in pancreas, skeletal muscle, lung and brain (PubMed:8227358). Expressed at intermediate level in kidney, liver and heart (PubMed:8227358).

亚细胞定位

Nucleus speckle

关键词

3D-structure Acetylation Activator Alternative splicing Direct protein sequencing Isopeptide bond mRNA processing mRNA splicing Nucleus Phosphoprotein

外部链接

UniProt: Q14498

NCBI Gene

GeneCards