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RASSF6 Q6ZTQ3

含Ras结合域蛋白6

蛋白质信息 (UniProt)

含Ras结合域蛋白6

Q6ZTQ3

功能描述

参与细胞凋亡的诱导,通过caspase依赖和caspase非依赖途径。可能作为Ras效应蛋白起作用。可能抑制血清诱导的NF-kappa-B基础水平(通过相似性)。{ECO:0000250, ECO:0000269|PubMed:17367779}。

组织特异性

Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart.

关键词

Alternative splicing Apoptosis Phosphoprotein Proteomics identification Reference proteome