RASSF5 Q8WWW0

含Ras关联结构域蛋白5 (新Ras效应因子1) (淋巴组织中富集的细胞粘附和极化调节因子) (RAPL)

功能描述

潜在的肿瘤抑制因子。似乎参与淋巴细胞粘附，通过将T细胞受体或趋化因子刺激后的RAP1A激活与整合素激活联系起来。Isoform 2刺激淋巴细胞极化和ITGAL/LFA-1的斑块样分布，从而增强与ICAM1的粘附。与RAP1A一起可能参与微管生长的调节。Isoform 2与激活的RAP1A的结合是伤口愈合过程中内皮细胞定向移动所必需的。可能参与Ras凋亡功能的调节。RASSF5-STK4/MST1复合物可能介导HRAS和KRAS诱导的细胞凋亡。 {ECO:0000269|PubMed:12676952, ECO:0000269|PubMed:12845325, ECO:0000269|PubMed:15569673}。

组织特异性

Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.

亚细胞定位

Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.