含Ras结合域蛋白2
含Ras结合域蛋白2
P50749功能描述
潜在的肿瘤抑制因子。作为KRAS特异性效应蛋白。可能促进细胞凋亡和细胞周期停滞。通过保护STK3/MST2免受蛋白酶体降解来使其稳定。 {ECO:0000269|PubMed:12732644, ECO:0000269|PubMed:16012945, ECO:0000269|PubMed:19525978}。
组织特异性
Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.
亚细胞定位
Nucleus. Cytoplasm. Chromosome, centromere, kinetochore
关键词